Konstantinos Gerasimidis


Senior Lecturer Clinical Nutrition


University of Glasgow


School of Medicine, Dentistry & Nursing,
R3.09 Level 3, New Lister Building, Glasgow Royal Infirmary


University of Glasgow
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Konstantinos Gerasmidis


Senior Lecturer Clinical Nutrition


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Konstantinos Gerasimidis


Senior Lecturer Clinical Nutrition


University of Glasgow


School of Medicine, Dentistry & Nursing,
R3.09 Level 3, New Lister Building, Glasgow Royal Infirmary


University of Glasgow
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ResearchGate


Dr Konstantinos Gerasimidis


Dr Konstantinos Gerasimidis is Senior Lecturer in Clinical Nutrition. He has graduated in Nutrition and Dietetics and completed his postgraduate studies in Clinical Nutrition. During his doctoral research at the University of Glasgow, he explored the effect of exclusive enteral nutrition on the gut microbiota and nutritional status of children with Crohn’s disease. He holds an honorary contract as Clinical Paediatric Nutrition Scientist with the National Health Service at Greater Glasgow and Clyde. Affiliations and memberships He is the Allied Health Professional representative in the Nutrition Committee of the European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN).


Selected publications


C Quince, UZ Ijaz, N Loman, AM Eren, D Saulnier, J Russell, SJ Haig, ST Calus, J Quick, A Barclay, M Bertz, M Blaut, R Hansen, P McGrogan, RK Russell, C Edwards, and K Gerasimidis
Extensive modulation of the fecal metagenome in children with Crohn's disease during exclusive enteral nutrition
American Journal of Gastroenterology, 110:1718-1729, 2015. DOI:10.1038/ajg.2015.357
K Gerasimidis, O Keane, I Macleod, DM Flynn, CM Wright
A four-stage evaluation of the Paediatric Yorkhill Malnutrition Score in a tertiary paediatric hospital and a district general hospital
British Journal of Nutrition, 104 (5), 751-756, 2010 DOI: 10.1017/S0007114510001121
K Gerasimidis, M Bertz, L Hanske, J Junick, O Biskou, M Aguilera, V Garrick, RK Russell, M Blaut, P McGrogan, CA Edwards
Decline in Presumptively Protective Gut Bacterial Species and Metabolites Are Paradoxically Associated with Disease Improvement in Pediatric Crohn’s Disease During Enteral Nutrition
Inflammatory Bowel Diseases, 20(5)1:861-871, 2014 DOI: 10.1097/MIB.0000000000000023


Richard Russell


Honorary Clinical Associate Professor and Consultant Paediatric Gastroenterologist


University of Glasgow


Department of Paediatric Gastroenterology, The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


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Richard Russell


Honorary Clinical Associate Professor and Consultant Paediatric Gastroenterologist


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Richard Russell


Honorary Clinical Associate Professor and Consultant Paediatric Gastroenterologist


University of Glasgow


Department of Paediatric Gastroenterology, The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


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Professor Richard Russell


Professor Richard Russell is currently one of four Consultant Paediatric Gastroenterologists working in Yorkhill Childrens Hospital in Glasgow. He is the lead for IBD services. His main research interest is in IBD and he has presented and published widely on this subject. Dr Russell has previously led a national multicentre study investigating the genetics of early onset inflammatory bowel disease in Scotland that resulted in the award of a PhD. The work has now moved forward to form part of an international adult/paediatric genetics consortium with published work in Nature and Nature Genetics. He is a member of the UK and European IBD working groups. Dr Russell is one of two paediatric members of the UK IBD audit group. He is moving forward with establishing both clinical and scientific studies in paediatric IBD within Scotland and beyond.


Selected publications


L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, et al.,
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature, 491 (7422), 119-124, 2012. DOI:10.1038/nature11582
A Levine, A Griffiths, J Markowitz, DC Wilson, D Turner, RK Russell, J Fell, FM Ruemmele, T Walters, M Sherlock, M Dubinsky, JS Hyams
Pediatric modification of the Montreal classification for inflammatory bowel disease: The Paris classification
Inflammatory Bowel Diseases, 17(6)104:1314-1421, 2011 DOI: 10.1002/ibd.21493


Richard Hansen


Consultant Paediatric Gastroenterologist


University of Glasgow


Department of Paediatric Gastroenterology, The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


University of Glasgow
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Richard Hansen


Consultant Paediatric Gastroenterologist


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Richard Hansen


Consultant Paediatric Gastroenterologist


University of Glasgow


Department of Paediatric Gastroenterology, The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


University of Glasgow
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Dr Richard Hansen


My main research interest is the gastrointestinal mucosal microbiota and its importance in paediatric disease, particularly inflammatory bowel disease. I am particularly interested in the molecular characterisation of the microbiota and its subsequent modification for the purposes of therapeutic effect. This theme of microbial therapeutics fits nicely into the concept of stratified medicine since the microbiota is highly individualistic yet also modifiable. Being a paediatrician, I am naturally interested in how the gut microbiota develops as the child grows and matures, particularly at the earliest stages of microbial colonisation. This area of research is a natural extension of my CSO-funded PhD studies during which I was the first to catalogue and publish the colonic microbiota in paediatric IBD at the onset of disease. I currently hold a competitive fellowship supporting the development of microbial therapeutic studies, awarded by NHS Research Scotland. In addition to my research interests, I have clinical interests in paediatric inflammatory bowel disease, liver disease and Helicobacter pylori. I am clinical lead for paediatric hepatology and paediatric endoscopy training in the West of Scotland and am the Scottish endoscopy representative on British Society of Paediatric Gastroenterology, Hepatology and Nutrition. I am co-hosting the 2017 meeting of British Society of Paediatric Gastroenterology, Hepatology and Nutrition and the 2019 meeting of European Society of Paediatric Gastroenterology, Hepatology and Nutrition in Glasgow.


Selected publications


R Hansen, Rk Russell, C Reiff, P Louis, F McIntosh, SH Berry, I Mukhopadhya, MW Bisset, AR Barclay, J Bishop, DM Flynn, P McGrogan, S Loganathan, G Mahdi, HJ Flint, EM El-Omar, GL Hold
Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis.
The American Journal of Gastroenterology, 107(12), 1913-22, 2012. DOI:10.1038/ajg.2012.335
I Mukhopadhya, R Hansen, EM El-Omar, GL Hold
IBD—what role do Proteobacteria play?
Nature reviews Gastroenterology & hepatology, 9(4), 219, 2012. DOI: 10.1038/nrgastro.2012.14


Simon Milling


Professor of Immunology (Immunology), Associate - Life Sciences (School of Life Sciences)


University of Glasgow


B421 Level B4, Iii - Gbrc,
University Place, Glasgow G12 8TA


University of Glasgow
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Simon Milling


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Simon Milling


Professor of Immunology (Immunology), Associate - Life Sciences (School of Life Sciences)


University of Glasgow


B421 Level B4, Iii - Gbrc,
University Place, Glasgow G12 8TA


University of Glasgow
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Professor Simon Milling


My lab works on the biology of the intestine, with two specific areas of special interest. First, we focus on the biology of dendritic cells, and how these cells respond to infectious or inflammatory stimuli. We study the functions of dendritic cell subsets in vivo, using samples from mice and from people. The aim of this work is to understand the vital roles that intestinal dendritic cells play in the induction and polarisation of adaptive immune responses against pathogens. Second, we study the pathology of a family of human inflammatory diseases that may be influenced by the intestinal immune system, using blood samples and available tissue biopsies. These include ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel disease, and alopecia areata. We hope to use this information to manipulate the immune response, to inhibit or even prevent inflammatory pathology.


Selected publications


V Cerovic, SA Houston, CL Scott, A Aumeunier, U Yrlid, AM Mowat, SWF Milling
Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells.
Mucosal Immunology, 6(1)104, 2013. DOI: 10.1038/mi.2012.53
V Cerovic, CC Bain, AM Mowat, SWF Milling
Intestinal macrophages and dendritic cells: what's the difference?
Trends in immunology, 35(6), 270-277, 2014. DOI: 10.1016/j.it.2014.04.003


Umer Ijaz


Lecturer in Information Engineering, NERC Independent Research Fellow, Lord Kelvin Adam Smith Leadership Fellow


University of Glasgow


Room 625, Rankine Building,
School of Engineering Oakfield Avenue, University of Glasgow, Glasgow, G12 8LT


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Uer Ijaz


Lecturer in Information Engineering, NERC Independent Research Fellow, Lord Kelvin Adam Smith Leadership Fellow


University of Glasgow


Room 625, Rankine Building,
School of Engineering Oakfield Avenue, University of Glasgow, Glasgow, G12 8LT


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Dr Umer Zeeshan Ijaz


I lead the Environmental 'Omics Lab in Infrastructure & Environment Division, School of Engineering that I established soon after I was awarded the NERC Independent Research Fellowship back in November, 2014. The purpose of my research is to integrate different sources of 'omics data (metagenomics, metatranscriptomics, metabolomics, and metaproteomics) in environmental science for microbial community analysis. The computational based comparative analysis of DNA sequences may provide information about genome structure, gene function, metabolic and regulatory pathways, how microbial genomes evolve, how they exist in a community and how they compete for resources whether they work together in a symbiosis or otherwise.


Selected publications


BN Parsons*, UZ Ijaz*, R D'Amore, M Burkitt, R Eccles, L Lenzi, CA Duckworth, AR Moore, L Tiszlavicz, A Varro, N Hall, and DM Pritchard
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.
PLoS Pathogens, 13(11), 2017. DOI:10.1371/journal.ppat.1006653
ST Calus, UZ Ijaz*, and A Pinto*
NanoAmpli-Seq: A workflow for amplicon sequencing from mixed microbial communities on the nanopore sequencing platform
bioRxiv, 244517, 2018. DOI: 10.1101/244517


Christine Edwards


Professor of Nutritional Physiology (Medicine), Associate (Institute of Health and Wellbeing)


University of Glasgow


School of Medicine, Dentistry & Nursing,
Room 3.05, New Lister Building, Glasgow Royal Infirmary


University of Glasgow
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?name?


Professor of Nutritional Physiology (Medicine), Associate (Institute of Health and Wellbeing)


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Christine Edwards


Professor of Nutritional Physiology (Medicine), Associate (Institute of Health and Wellbeing)


University of Glasgow


School of Medicine, Dentistry & Nursing,
Room 3.05, New Lister Building, Glasgow Royal Infirmary


University of Glasgow
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Professor Christine A Edwards


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Selected publications


M Fallani, D Young, J Scott, E Norin, S Amarri, R Adam, M Aguilera, S Khanna, A Gil, CA Edwards, J Doré
Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics.
Journal of pediatric gastroenterology and nutrition , 51(1), 77-84, 2010. DOI:10.1097/MPG.0b013e3181d1b11e
W Mullen, CA Edwards, A Crozier
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions.
British Journal of Nutrition, 96(1), 107-116. DOI: 10.1079/BJN20061809


Dan Gaya


Consultant Gastroenterologist and Honorary Clinical Associate Professor


University of Glasgow


Gastroenterology Unit, Glasgow Royal Infirmary, Glasgow, UK


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Cure Crohn's Colitis


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Dan Gaya


Consultant Gastroenterologist and Honorary Clinical Associate Professor


University of Glasgow


Gastroenterology Unit, Glasgow Royal Infirmary, Glasgow, UK


ResearchGate
Cure Crohn's Colitis


Dr Dan Gaya


Dr Daniel Gaya is a consultant gastroenterologist at Glasgow Royal Infirmary. He is also an Honorary Associate Professor at the University of Glasgow Medical School. He has received comprehensive training in Glasgow, Edinburgh, London & Chicago in acute and general medicine, luminal gastroenterology, hepatology and therapeutic endoscopy. Dr Gaya's sub-specialist interest is inflammatory bowel disease (IBD) and he receives tertiary referrals for the management of complex IBD cases and set up the transition clinic for adolescents with IBD with colleagues at the Royal Hospital for Children in Glasgow. Dr Gaya is board member of the Scottish IBD charity C³ (www.curecrohnscolitis.org) and a member of the British Society of Gastroenterology IBD Committee. Dr Gaya is in receipt of a research fellowship from the Chief Scientist Office (CSO) of the Scottish Government to undertake a comprehensive IBD research programme in the West of Scotland. His main research interests include novel clinical trials in IBD, environmental/dietary factors in IBD management/pathogenesis and faecal biomarkers. He has recently been awarded funding to explore the role of faecal transplantation in ulcerative colitis (MRC £2.6M), environmental factors effecting disease outcome in IBD (CSO £250K) and the link between intestinal inflammation and spondyloarthopathy (Arthritis UK £200K).


Selected publications


T Barroso, F Conway,S Emel, D McMillan, D Young, H Karteszi, D Gaya, K Gerasimidis.
Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics.
Annals of Gastroenterology, 31(5)566-571, 2018. DOI:10.20524/aog.2018.0280
CS Probert, S Sebastian, D Gaya, PJ Hamlin, G Gillespie, A Rose, H Tate, C Wheeler, PM Irving.
Golimumab induction and maintenance for moderate to severe ulcerative colitis: results from GO-COLITIS (Golimumab: a Phase 4, UK, open label, single arm study on its utilization and impact in ulcerative Colitis).
BMC Open Gastroenterology, 5(1). DOI: 10.1136/bmjgast-2018-000212


Chris Quince


Lecturer in Biological Systems Modelling


University of Warwick


WMS - Microbiology and Infection, University of Warwick, Coventry, CV4 7AL


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Chris Quince


Lecturer in Biological Systems Modelling


University of Warwick


WMS - Microbiology and Infection, University of Warwick, Coventry, CV4 7AL


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Christopher Quince


Metagenomics coupled to next generation sequencing has transformed our understanding of the microbial world. It has allowed us to directly determine community structure and function in situ from the DNA of the organisms present. This is revolutionising microbial ecology. My research consists of the development of improved statistical and bioinformatics tools for interpreting this sequence data. These tools exploit advanced methods from machine learning and Bayesian statistics. I work on both 16S rRNA gene amplicon data, having developed the AmpliconNoise algorithm for error removal from 454 pyrosequenced amplicons (http://code.google.com/p/ampliconnoise/) and shotgun metagenomics for example the CONCOCT algorithm for automated genome extraction from shotgun metagenome reads (https://github.com/BinPro/CONCOCT). In addition, I also develop Bayesian statistical models for interpreting microbial community structure addressing questions such as are enterotypes real features of the human gut microbiome and are microbial communities neutrally assembled? In collaboration with numerous groups around the world I apply these methods to both environmental and host-associated microbial communities. For instance, with Dr Konstantinos Gerasimidis (Nutrition Group - University of Glasgow -- http://www.gla.ac.uk/schools/medicine/staff/konstantinosgerasimidis/) and Dr Nick Loman (University of Birmimgham - http://pathogenomics.bham.ac.uk/clinicogenomics/) I have resolved the changes in gut microbiota composition of children with Crohn's disease during treatment with exclusive enteral nutrition. This could potentially lead to improved therapeutic strategies. With Dr Gavin Collins (University of Galway - http://www.nuigalway.ie/microbiology/dr_gavin_collins.html) I study the structure of anaerobic digestion reactor communities. More efficient AD digesters will provide more effective biogas production from wastewater, reducing pollution and providing a renewable energy resource. I am currently employed as an MRC Principal Research Fellow as part of the Cloud Computing for Microbial Bioinformatics (CLIMB) consortium (http://www.climb.ac.uk/).


Selected publications


RC Edgar, BJ Haas, JC Clemente, C Quince, R Knight.
UCHIME improves sensitivity and speed of chimera detection.
Bioinformatics, 27(16), 2194-2000, 2011. DOI:10.1093/bioinformatics/btr381
C Quince, A Lanzen, RJ Davenport, PJ Turnbaugh.
Removing noise from pyrosequenced amplicons.
BMC Bioinformatics, 12(1), 38, 2011. DOI: 10.1186/1471-2105-12-38


George Raptis


Consultant in Paediatric Allergy and General Paediatrics, Honorary Clinical Senior Lecturer


University of Glasgow


The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


University of Glasgow
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George Raptis


Consultant in Paediatric Allergy and General Paediatrics, Honorary Clinical Senior Lecturer


University of Glasgow


The Royal Hospital for Children,
1345 Govan Road, Glasgow G51 4TF, UK


University of Glasgow
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Dr George Raptis


Dr George Raptis is an Honorary Clinical Senior Lecturer and Consultant in Paediatric Allergy, based at the Royal Hospital for Children, Glasgow. George's main interest is to understand further the pathophysiology of gastrointestinal allergy in children. Better understanding of the microenvironment of the gastrointestinal mucosa and mechanisms of allergy will enable researchers and clinicians to develop means to prevent or induce immunological tolerance. Additionally, he is striving to develop a model of care for allergic patients that aims to consider each stage of the allergic disease continuum and propose a number of strategies to provide consumer-focussed, best care. Dr Raptis is committed to contributing to the development of research in this field in order to alleviate the impact of allergies on sufferers.



Gordon Ramage


Professor (Dental School), Associate Academic (Institute of Infection Immunity and Inflammation)


University of Glasgow


School of Medicine, Dentistry & Nursing, L16 Level 9, 378 Sauchiehall Street, Glasgow Dental Hospital & School


University of Glasgow
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Gordon Ramage


Professor (Dental School), Associate Academic (Institute of Infection Immunity and Inflammation)


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Gordon Ramage


Professor (Dental School), Associate Academic (Institute of Infection Immunity and Inflammation)


?uni?


School of Medicine, Dentistry & Nursing, L16 Level 9, 378 Sauchiehall Street, Glasgow Dental Hospital & School


University of Glasgow
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Professor Gordon Ramage


Gordon is an intelligent researcher with excellent networking skills. An up and coming clinical scientist with interests in biofilms, oral microbiology, and antifungal development.


Selected publications


PVan Dijck, J Sjollema, BPA Cammue, K Lagrou, J Berman, C d’Enfert, et al.,
Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.
Microbial Cell, 5(7), 300-326, 2018. DOI: 10.15698/mic2018.07.638
S Weidt, J Haggarty, R Kean, CI Cojocariu, PJ Silcock, R Rajendran, G Ramage, KEV Burgess.
A novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms.
Metabolomics, 12(12), 189, 2016. DOI: 10.1007/s11306-016-1134-2


Dan Walker


Professor (Bacteriology), Associate - Life Sciences (School of Life Sciences), Associate (Biochemistry & Cell Biology)


University of Glasgow


RB226 Level B2, Iii - Gbrc, University Place, Glasgow G12 8TA


University of Glasgow
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?name?


Professor (Bacteriology), Associate - Life Sciences (School of Life Sciences), Associate (Biochemistry & Cell Biology)


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Dan Walker


Professor (Bacteriology), Associate - Life Sciences (School of Life Sciences), Associate (Biochemistry & Cell Biology)


University of Glasgow


RB226 Level B2, Iii - Gbrc, University Place, Glasgow G12 8TA


University of Glasgow
ResearchGate
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Professor Daniel Walker


We aim to develop highly selective and potent protein antibiotics (bacteriocins) for the treatment of chronic bacterial infections and for use in agricultural applications. In addition, we are interested in determining the mechanism of action of bacteriocins, studying fundamental aspects of membrane biogenesis in Gram-negative bacteria and deleloping cross-linking stratagies for structural proteomics. Current research projects include: Protein antibiotics as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Harnessing bacteriocins active against bacterial plant pathogens. Mapping protein-protein interactions in the translocation and assembly module (TAM) complex involved in autotransporter biogenesis. Development of cross-linking strategies for structural proteomics


Selected publications


K Mosbahi, M Wojnowska, A Albalat, D Walker. , 115(26), pp. 6840-6845.
Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein.
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6840-6845, 2018. DOI: 10.1073/pnas.1800672115
P White, A Joshi, P Rassam, NG Housden, R Kaminska, JD Goult, C Redfield, LC McCaughey, D Walker, S Mohammed, C Kleanthous
Exploitation of an iron transporter for bacterial protein antibiotic import.
Proceedings of the National Academy of Sciences of the United States of America, 114(45), 12051-12056, 2017. DOI: 10.1073/pnas.1713741114